Colorado vs. USC odds, spread, line: 2023 college football picks, Deion Sanders predictions by proven model

Heisman Trophy holder Caleb Williams has the opportunity to further strengthen his case for retaining the award as he leads the No. 8 USC Trojans against Deion Sanders’ Colorado Buffaloes in a Pac-12 matchup this Saturday at Folsom Field in Boulder, Co. The 6-foot-1 junior from Washington, D.C. has dominated passing statistics despite only playing 12 quarters of football. Additionally, Williams has propelled the Trojans (4-0, 2-0 in Pac-12) to an undefeated record and a strong position in the race for a spot in the College Football Playoffs. On the flip side, the Buffaloes (3-1, 0-1) have already surpassed their win total from last season.

SportsLine consensus has the Trojans a 21.5-point advantage over Colorado in the latest USC vs. Colorado odds. The over/under is 73 points. SportsLine’s proven computer model can provide you with college football predictions and betting advice before you make any Colorado vs. USC picks.

Every FBS college football game is simulated 10,000 times using the SportsLine Projection Model. With its top-rated college football picks against the spread, the proprietary computer model has generated almost $2,500 in profit for $100 players since its inception. Those following the model have seen huge profits.

You can check out the model’s CFB picks now on SportsLine. Here are a few college football odds and trends for Colorado vs. USC:

USC is able to cover

Caleb Williams & Co. have a plus matchup going up against the Colorado pass defense. In addition to ranking third in the country in passing yards per game (377.2 yards), the Trojans will face a Buffaloes defense that concedes 269.2 passing yards per game, 111th in the nation. Last week, Colorado lost to Oregon by 217 passing yards and three touchdowns in just the first half.

As a result, the Buffaloes have struggled to protect their quarterback this season due to multiple transfers and a true freshman on their offensive line. Colorado gives up 5.75 sacks per game, which is the second highest among 130 FBS programs behind only Old Dominion (6.50). Find out which team to pick.

Colorado’s ability to cover

As one of the best passing attacks in the country, the Buffaloes are led by quarterback Shedeur Sanders. Colorado ranks fifth in the nation for passing yards per game (353.2). In the country, Sanders has completed 76.9% of his passes, which is the fifth highest rate.

In addition, the Buffaloes have done an excellent job of winning the turnover battle this season. Colorado has intercepted seven passes this year, which is tied for fifth in the nation, and forced 11 turnovers total. The team ranks fourth in the nation with a +1.75 turnover margin per game. Find out which team to pick here.

Picking USC vs. Colorado

SportsLine’s model expects the teams to combine for 68 points, with one side of the spread hitting in well over 50% of simulations. You can check out the model’s picks at SportsLine.